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Updated: Apr 6, 2026

A Cell Culture Model of Resistance Arteries
10:54

A Cell Culture Model of Resistance Arteries

Published on: September 8, 2017

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Whence Resistance?

Christopher A Guidry1, Stephen W Davies1, Rosemarie Metzger1

  • 11 Department of Surgery, The University of Virginia Health System , Charlottesville, Virginia.

Surgical Infections
|July 18, 2015
PubMed
Abstract

Insights

Antimicrobial pressure significantly drives resistance development in intensive care units. Limiting antibiotic use is more effective than isolation for reducing antimicrobial resistance.

Area of Science:

  • Infectious Diseases
  • Critical Care Medicine
  • Microbiology

Background:

  • Antimicrobial resistance arises from interactions between bacteria, antimicrobial pressure, and genes.
  • Understanding antimicrobial pressure's role in resistance is crucial for infection control.

Purpose of the Study:

  • To evaluate the impact of antimicrobial pressure on resistance development in a surgical intensive care unit.

Main Methods:

  • Reviewed prospectively collected data on ICU-acquired infections in surgical/trauma patients over 6 years.
  • Defined resistant gram-negative (rGNR) and gram-positive (rGPC) pathogens, including MRSA and VRE.
  • Assessed antibiotic use, prior treatments, and concurrent infections for each resistant case.

Main Results:

  • Identified 330 resistant infections (237 rGNR, 93 rGPC).
  • Most resistant infections occurred during antibiotic therapy (65% rGNR, 50.6% rGPC).
  • De novo resistance emergence appeared more frequent than patient-to-patient transmission.

Conclusions:

  • Antimicrobial pressure substantially influences the development of subsequent infections.
  • Reducing antimicrobial usage is a more effective strategy than enhanced isolation for combating resistance.
  • Findings support prioritizing antimicrobial stewardship to mitigate resistance in ICUs.

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