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Related Concept Videos

Resistance01:19

Resistance

7.9K
When a current moves through any conductor, the conductor causes some level of difficulty for the current to flow. The measure of that difficulty is known as the resistance of the material and is represented by R. Every material has its own resistance. In the case of conductors, heat is emitted whenever a current passes through them. Resistance depends on the resistivity of the material. Resistivity is a characteristic of the material used to fabricate electrical components, whereas the...
7.9K
Ohm's Law01:19

Ohm's Law

2.9K
Resistors are fundamental components in electrical circuits, often manufactured from metallic alloys or carbon compounds. They model a material's ability to resist the flow of electric current, a characteristic that is crucial in controlling and regulating electrical power within a circuit.
This current-resisting behavior of resistors is governed by Ohm's law, which states that the voltage across a resistor is directly proportional to the current flowing through it.
2.9K
Ohm's Law01:21

Ohm's Law

13.1K
Many materials exhibit a simple relationship between the values of current, voltage, and resistance, known as Ohm’s law. The current that flows through most substances is directly proportional to the voltage applied to them. The German physicist Georg Simon Ohm (1787–1854) was the first to demonstrate experimentally that the current in a metal wire is directly proportional to the voltage applied. Any material, component, or device that obeys Ohm’s law, where the current...
13.1K
Vascular Resistance01:20

Vascular Resistance

13.4K
Vascular resistance is a critical concept in understanding blood flow dynamics in the circulatory system. It refers to the resistance that blood encounters as it flows through the blood vessels. This resistance is a key factor in determining blood pressure and cardiac workload.
The primary determinants of vascular resistance are vessel diameter, blood viscosity, and vessel length. Among these, vessel diameter plays the most significant role due to the fourth power relationship described by...
13.4K
Resistivity01:22

Resistivity

6.3K
When a voltage is applied to a conductor, an electrical field is generated, and charges in the conductor feel the force due to the electrical field. The current density that results depends on the electrical field and the properties of the material. In some materials, including metals at a given temperature, the current density is approximately proportional to the electrical field. In these cases, the current density can be modeled as:
6.3K
Resistors In Series01:10

Resistors In Series

7.5K
A resistor is an ohmic device that limits the flow of charge in a circuit. Most circuits have more than one resistor. If several resistors are connected together and connected to a battery, the current supplied by the battery depends on the equivalent resistance of the circuit. The equivalent resistance of a combination of resistors depends on both their individual values and how they are connected. The simplest combination of resistors is the series combination. 
In a series circuit, the...
7.5K

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Updated: Apr 6, 2026

A Cell Culture Model of Resistance Arteries
10:54

A Cell Culture Model of Resistance Arteries

Published on: September 8, 2017

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Whence Resistance?

Christopher A Guidry1, Stephen W Davies1, Rosemarie Metzger1

  • 11 Department of Surgery, The University of Virginia Health System , Charlottesville, Virginia.

Surgical Infections
|July 18, 2015
PubMed
Summary
This summary is machine-generated.

Antimicrobial pressure significantly drives resistance development in intensive care units. Limiting antibiotic use is more effective than isolation for reducing antimicrobial resistance.

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Fabrication and Validation of an Organ-on-chip System with Integrated Electrodes to Directly Quantify Transendothelial Electrical Resistance
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Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection
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Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection

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Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection
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Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection

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Area of Science:

  • Infectious Diseases
  • Critical Care Medicine
  • Microbiology

Background:

  • Antimicrobial resistance arises from interactions between bacteria, antimicrobial pressure, and genes.
  • Understanding antimicrobial pressure's role in resistance is crucial for infection control.

Purpose of the Study:

  • To evaluate the impact of antimicrobial pressure on resistance development in a surgical intensive care unit.

Main Methods:

  • Reviewed prospectively collected data on ICU-acquired infections in surgical/trauma patients over 6 years.
  • Defined resistant gram-negative (rGNR) and gram-positive (rGPC) pathogens, including MRSA and VRE.
  • Assessed antibiotic use, prior treatments, and concurrent infections for each resistant case.

Main Results:

  • Identified 330 resistant infections (237 rGNR, 93 rGPC).
  • Most resistant infections occurred during antibiotic therapy (65% rGNR, 50.6% rGPC).
  • De novo resistance emergence appeared more frequent than patient-to-patient transmission.

Conclusions:

  • Antimicrobial pressure substantially influences the development of subsequent infections.
  • Reducing antimicrobial usage is a more effective strategy than enhanced isolation for combating resistance.
  • Findings support prioritizing antimicrobial stewardship to mitigate resistance in ICUs.