Electrophoretic study of proteins associated with pseudo-exfoliation syndrome

Lens capsule and aqueous humour from cataractous eyes with and without pseudo-exfoliation syndrome have been studied by SDS-PAGE electrophoresis. Four cataractous lenses with and four without pseudo-exfoliation were used. The pseudo-exfoliation positive capsule revealed two polypeptides not present in the control material, and accordingly, these components were regarded to be pseudo-exfoliation specific. The molecular weight of the respective polypeptides was estimated to be 14,400 and 16,300. No marked differences were found between the pseudo-exfoliation positive and negative aqueous humours.