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Related Experiment Video

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Correlation between Systemic Oxidative Stress and Intraocular Pressure Level.

Masaki Tanito1, Sachiko Kaidzu2, Yasuyuki Takai2

  • 1Division of Ophthalmology, Matsue Red Cross Hospital, Matsue, Shimane, Japan; Department of Ophthalmology, Shimane University Faculty of Medicine, Izumo, Shimane, Japan.

Plos One
|July 18, 2015
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Summary

Lower systemic antioxidant capacity, measured by biological antioxidant potential (BAP), is linked to higher intraocular pressure (IOP) in glaucoma patients. This suggests BAP plays a role in the development of open-angle glaucoma.

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Area of Science:

  • Ophthalmology
  • Biochemistry
  • Oxidative Stress Research

Background:

  • Glaucoma pathogenesis is hypothesized to involve local and systemic oxidative stress, impacting intraocular pressure (IOP) and optic nerve damage.
  • Previous studies indicated lower systemic antioxidative capacity in open-angle glaucoma patients compared to controls.
  • This study investigates the correlation between IOP and systemic prooxidant/antioxidant levels in glaucoma patients.

Purpose of the Study:

  • To assess the relationship between intraocular pressure (IOP) and systemic levels of prooxidants and antioxidants.
  • To analyze blood biochemistry in patients with glaucoma to understand the role of oxidative stress in IOP elevation.

Main Methods:

  • Collected peripheral blood samples from Japanese patients with primary open-angle glaucoma (n=206), exfoliation syndrome (n=199), and controls (n=126).
  • Measured serum lipid peroxides (dROM), ferric-reducing activity (BAP), and thiol antioxidant activity (SH) using a free radical analyzer.
  • Classified patients into IOP quartiles (Q1-Q4) and used logistic regression to analyze associations between biochemical markers and IOP levels, adjusting for demographic factors.

Main Results:

  • Biological antioxidant potential (BAP) levels differed significantly among IOP groups (p=0.0115).
  • Lower BAP levels were observed in higher IOP groups (Q4 and Q3) compared to the lowest IOP group (Q1).
  • After demographic adjustment, lower BAP values were significantly associated with higher IOP classifications (Q3, Q4), while dROM and SH levels showed no significant differences.

Conclusions:

  • Reduced systemic antioxidant capacity, specifically measured by ferric-reducing activity (BAP), is implicated in the pathogenesis of open-angle glaucoma.
  • This diminished antioxidant capacity appears to contribute to intraocular pressure elevation in glaucoma patients.