Related Experiment Video
Updated: Apr 6, 2026

Zebra II as A Novel System to Record Electrophysiological Signals in Zebrafish
Published on: August 16, 2024
Venlafaxine induced QTc interval prolongation in a therapeutic dose
1Department of Psychiatry, Rajarajeswari Medical College & Hospital, Bangalore 560074, India.
Abstract:
This is the second report of a patient developing severe prolongation of QTc interval with a dose of 300mg/day of venlafaxine; on stopping it, QTc reverted to normalcy. Venlafaxine was restarted and maintained at 150mg/day, with QTc interval remaining normal, indicating, that it has a dose-dependent effect on QTc interval. Venlafaxine was not changed as she had responded best to this drug compared to any other antidepressant. Over 20 years, the only time she had a period of 5 years of remission, was when she was on 75mg of venlafaxine/day.
More Related Videos
04:29Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression
Published on: January 7, 2019
10:41Laser-Induced Action Potential-Like Measurements of Cardiomyocytes on Microelectrode Arrays for Increased Predictivity of Safety Pharmacology
Published on: September 13, 2022
Related Concept Videos
ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias
Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance
A study on guinea pigs examined the...
Antiepileptic Drugs: Potassium Channel Activators
Ezogabine has gained approval as an adjunctive treatment...
Antiarrhythmic Drugs: Class IV Agents as Calcium Channel Blockers
Verapamil, a calcium channel blocker, inhibits calcium movement across myocardial cell membranes and vascular smooth muscle. This results in the dilation of coronary and...
Antiarrhythmic Drugs: Class III Agents as Potassium Channel Blockers
Depolarizing Blockers: Pharmocokinetics