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Evaluation of relationship between GRM3 polymorphisms and cognitive function in schizophrenia of Han Chinese
Ming Chang1, Linyan Sun2, Xinmei Liu2
1School of Management, Xi'an Jiaotong University, Xi'an, China; School of Psychology, Shaanxi Normal University, Xi'an, China.
Abstract:
Recently, the novel SNP rs12704290 in GRM3 was identified in a genome-wide association study on schizophrenia susceptibility. Our study was to investigate the association of 29 selected SNPs (including rs12704290) with schizophrenia and to evaluate any possible relationship between them and cognition related to schizophrenia. The SNPs were analyzed in 1115 unrelated schizophrenic patients and 2289 healthy controls. The results showed significant associations between these SNPs and schizophrenia as well as with changes in cognition.
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