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Renal denervation does not prevent dehydration-induced natriuresis in sheep
R G Park1, J Clevers, M J McKinley
1Howard Florey Institute of Experimental Physiology, University of Melbourne, Parkville, Australia.
Acta Physiologica Scandinavica
|October 1, 1989
Summary
Water deprivation in sheep caused natriuresis, regardless of renal nerve activity. This suggests that the brain
Area of Science:
- Nephrology
- Physiology
- Endocrinology
Background:
- Water deprivation leads to increased plasma osmolality and sodium concentration.
- Previous studies suggested cerebral involvement in dehydration-induced natriuresis.
Purpose of the Study:
- To investigate the role of renal nerve activity in natriuresis during water deprivation.
- To determine the efferent pathway mediating cerebral influence on renal sodium excretion.
Main Methods:
- Sheep were subjected to water deprivation for 2 days.
- Renal nerves were extirpated in one group of sheep.
- Plasma osmolality and plasma Na concentration were measured.
- Renal denervation was confirmed by catecholamine fluorescence absence.
Main Results:
- Both normal and denervated sheep exhibited significant natriuresis during water deprivation.
- Both groups showed increased plasma osmolality and plasma Na concentration.
- Renal denervation was confirmed to be extensive.
Conclusions:
- Renal nerve activity does not mediate natriuresis during water deprivation.
- The efferent pathway for cerebral influence on renal sodium excretion likely involves hormonal mechanisms, not renal nerves.