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Related Concept Videos

Olfaction01:25

Olfaction

49.9K
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
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Physiology of Smell and Olfactory Pathway01:20

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Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
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Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

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The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
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Related Experiment Video

Updated: Apr 6, 2026

Isolating Nasal Olfactory Stem Cells from Rodents or Humans
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Cell-based microfluidic platform for mimicking human olfactory system.

Seung Hwan Lee1, Eun Hae Oh2, Tai Hyun Park3

  • 1School of Chemical and Biological Engineering, Seoul National University, Seoul 151-742, Republic of Korea.

Biosensors & Bioelectronics
|July 20, 2015
PubMed
Summary
This summary is machine-generated.

This study introduces a microfluidic device for detecting gaseous odorants using human olfactory receptors (hORs). The system successfully detects odorants via fluorescence, mimicking the human olfactory system for gas sensing.

Keywords:
Cell-based odorant detection systemGaseous odorantMicrofluidics platformOlfactory receptor

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Imaging Odor-Evoked Activities in the Mouse Olfactory Bulb using Optical Reflectance and Autofluorescence Signals
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Area of Science:

  • Biotechnology
  • Sensory Systems
  • Microfluidics

Background:

  • Mimicking the human olfactory system is crucial for odorant detection.
  • Existing cell-based systems often use liquid odorants, limiting real-world applicability.
  • Human olfactory receptors (hORs) are key to understanding smell perception.

Purpose of the Study:

  • To develop a microfluidic device for detecting gaseous odorants.
  • To create a system that more closely mimics the human olfactory system.
  • To enable real-time detection and discrimination of airborne odorants.

Main Methods:

  • Culturing hOR-expressing cells on a porous membrane within a two-compartment microfluidic device.
  • Supplying gaseous odorants to the upper compartment while maintaining cell viability in the lower aqueous compartment.
  • Detecting odorant-cell interactions via fluorescence signals generated by calcium influx.

Main Results:

  • Successful real-time detection of gaseous odorant molecules.
  • Dose-dependent fluorescence responses observed in the 0-2 ppm range.
  • Demonstrated ability of the system to discriminate between different gaseous odorants.
  • The system effectively mimics the human olfactory system's ability to detect airborne stimuli.

Conclusions:

  • The developed microfluidic device provides a novel platform for gaseous odorant detection.
  • This system offers a more biologically relevant approach compared to traditional liquid-phase methods.
  • The technology holds potential for advanced olfactory research and applications.