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Related Concept Videos

Satellite Stem Cells and Muscular Dystrophy01:21

Satellite Stem Cells and Muscular Dystrophy

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Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...
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Microscopic Anatomy of Skeletal Muscles01:13

Microscopic Anatomy of Skeletal Muscles

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Skeletal muscle cells, also called muscle fibers, are distinctly elongated, multi-nucleated, slender biological units. They are packed with specialized structures designed to facilitate their primary function, which is contraction.
The muscle sarcolemma is a plasma membrane enclosing each muscle cell that conducts electrical signals called action potentials. The sarcolemma extends into the cell to form T-tubules, ensuring the neural impulses are uniformly distributed across the entire muscle...
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Overview of Skeletal Muscle01:15

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Skeletal muscles are composed of a bundle of muscle fibers and are attached to bones through tendons. Each skeletal muscle fiber is a single muscle cell. The sarcolemma, the plasma membrane of a skeletal muscle cell, consists of a lipid bilayer and glycocalyx that supports muscle fibers. The sarcolemma extends into the muscle cells to form tubular structures called transverse or T-tubules. Each side of the T-tubules consists of a membrane-bound structure called the sarcoplasmic reticulum,...
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Formation of Muscle Fibers from Myoblasts01:13

Formation of Muscle Fibers from Myoblasts

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De novo myogenesis, or the formation of muscle fibers, begins during the early embryonic stages. The skeletal muscle is formed from somites– blocks of embryonic cell layers. The somites are further divided into dermatomes, myotomes, sclerotomes, and syndetomes. Among these, the myotomes give rise to muscle fibers.
Muscle progenitor cells (MPCs) are formed from the myotomes. MPCs express genes that encode the transcription factors Pax3 and Pax7. Along with Pax 3/7, other transcription...
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Skeletal Muscle Anatomy00:55

Skeletal Muscle Anatomy

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Skeletal muscle is the most abundant type of muscle in the body. Tendons are the connective tissue that attaches skeletal muscle to bones. Skeletal muscles pull on tendons, which in turn pull on bones to carry out voluntary movements.
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Structure of Cardiac Muscles01:13

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Cardiac muscle, or myocardium, is a specialized type of muscle found exclusively in the heart. Its unique structural and functional characteristics enable the heart to perform its vital role of pumping blood throughout the body continuously and rhythmically. The cardiac muscle cells, or cardiomyocytes, possess an endomysium and perimysium but do not have an epimysium.
Compared to skeletal muscles, cardiac muscle cells are small and mostly have a single nucleus. Additionally, they are usually...
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Related Experiment Video

Updated: Apr 6, 2026

Identification of Skeletal Muscle Satellite Cells by Immunofluorescence with Pax7 and Laminin Antibodies
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Identification of Skeletal Muscle Satellite Cells by Immunofluorescence with Pax7 and Laminin Antibodies

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Muscle stem cells on the edge.

Jason D Doles1, Bradley B Olwin1

  • 1Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309, United States.

Current Opinion in Genetics & Development
|July 20, 2015
PubMed
Summary

Muscle stem cell activation relies on gene expression control. This review explores how mRNA regulation impacts muscle aging and disease.

Area of Science:

  • Muscle stem cell biology
  • Molecular regulation of cell function
  • Aging and disease pathogenesis

Background:

  • Muscle stem cells (MuSCs) maintain skeletal muscle regeneration.
  • Activation of quiescent MuSCs requires precise control of gene expression.
  • Post-transcriptional mechanisms play a critical role in regulating MuSC function.

Purpose of the Study:

  • To review the role of post-transcriptional regulation in muscle stem cell activation.
  • To highlight the importance of mRNA homeostasis in MuSCs.
  • To discuss the implications of disrupted mRNA regulation in muscle aging and disease.

Main Methods:

  • Literature review focusing on post-transcriptional control mechanisms.
  • Analysis of studies investigating mRNA stability and translation in MuSCs.

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Isolation, Culture, and Transplantation of Muscle Satellite Cells
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Isolation, Culture, and Transplantation of Muscle Satellite Cells

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Isolation and Characterization of Satellite Cells from Rat Head Branchiomeric Muscles
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Isolation and Characterization of Satellite Cells from Rat Head Branchiomeric Muscles

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Related Experiment Videos

Last Updated: Apr 6, 2026

Identification of Skeletal Muscle Satellite Cells by Immunofluorescence with Pax7 and Laminin Antibodies
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Isolation, Culture, and Transplantation of Muscle Satellite Cells
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  • Examination of evidence linking mRNA dysregulation to muscle pathologies.

    • Main Results:

    • Post-transcriptional regulation, including mRNA stability and translation, is crucial for MuSC quiescence exit.
    • Aberrant mRNA homeostasis contributes to age-related decline in muscle regeneration.
    • Dysregulated mRNA processing is implicated in the pathogenesis of various muscle diseases.

    Conclusions:

    • Post-transcriptional control is a key determinant of muscle stem cell function.
    • Maintaining mRNA homeostasis is vital for healthy muscle aging.
    • Targeting post-transcriptional pathways may offer therapeutic strategies for muscle disorders.