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Related Concept Videos

Proteomics01:33

Proteomics

10.2K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
10.2K

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Related Experiment Video

Updated: Apr 6, 2026

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
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Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

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Advances in high-resolution quantitative proteomics: implications for clinical applications.

Sebastien Gallien1, Bruno Domon

  • 1a Luxembourg Clinical Proteomics Center (LCP), Luxembourg Institute of Health (LIH), Strassen, Luxembourg.

Expert Review of Proteomics
|July 21, 2015
PubMed
Summary

High-resolution mass spectrometry, particularly parallel reaction monitoring (PRM), enhances targeted quantitative proteomics. This technique offers superior selectivity and sensitivity for analyzing complex biological samples.

Keywords:
high-resolution and accurate-massmultiple reaction monitoringparallel reaction monitoringquadrupole-orbitrapselected reaction monitoringtargeted proteomics

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Area of Science:

  • Proteomics
  • Analytical Chemistry
  • Biomedical Research

Background:

  • Advances in high-resolution mass spectrometry (HRMS) enable new quantitative proteomics strategies.
  • Quadrupole-orbitrap mass spectrometers offer high resolving power and trapping capabilities.

Purpose of the Study:

  • To highlight the advantages of parallel reaction monitoring (PRM) for targeted quantitative proteomics.
  • To discuss the paradigm shift and enhanced flexibility in proteomic analysis workflows.

Main Methods:

  • Utilizing quadrupole-orbitrap mass spectrometers in parallel reaction monitoring (PRM) mode.
  • Leveraging high resolving power and trapping capabilities for selective and sensitive peptide analysis.
  • Implementing a new data acquisition scheme with dynamic parameter settings.

Main Results:

  • PRM provides unmatched selectivity and analytical sensitivity for complex samples.
  • Decoupling acquisition and data processing in PRM creates flexible analytical workflows.
  • Enhanced PRM acquisition schemes offer dynamic parameter adjustments.

Conclusions:

  • Parallel reaction monitoring (PRM) represents a significant advancement in targeted quantitative proteomics.
  • The technique's flexibility and performance have the potential to revolutionize future proteomic studies.
  • PRM is crucial for complex sample analyses in biomedical and clinical research.