Related Experiment Video
Updated: May 17, 2025
10:09
Characterization of Immune Cell-derived Extracellular Vesicles and Studying Functional Impact on Cell Environment
Published on: June 2, 2020
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Remodeling of immune system functions by extracellular vesicles
Deborah Neyrinck-Leglantier1,2,3, Marie Tamagne1,2,3, Raida Ben Rayana4
1Univ Paris Est-Creteil (UPEC), Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Mondor de la Recherche Biomédicale (IMRB), Creteil, France.
Frontiers in Immunology
|April 4, 2025
Summary
People living with HIV (PLWH) exhibit increased plasma microparticles (MPs) that drive immune cell dysfunction, hindering immune restoration and potentially causing comorbid conditions. Understanding MP phenotype is key to managing chronic immune activation.
Area of Science:
- Immunology
- Virology
- Cell Biology
Background:
- Chronic viral infections, like HIV, lead to persistent immune activation despite treatment.
- This chronic activation is linked to comorbidities such as cardiovascular disease and cancer.
- People living with HIV (PLWH) have elevated levels of plasma microparticles (MPs) with an immunomodulatory phenotype.
Purpose of the Study:
- To investigate the impact of MPs on immune cell function in PLWH.
- To determine if MP number and phenotype influence immune responses.
Main Methods:
- Examined plasma microparticles (MPs) from platelets, monocytes, and lymphocytes in PLWH and healthy donors (HDs).
- Assessed the interaction of these MPs with CD4+ and CD8+ T lymphocytes, monocytes, and dendritic cells (DCs).
Main Results:
- Interactions with MPs increased cytokine secretion (IFNg, IL2, IL6, IL12, IL17, TNFa) from immune cells.
- The functional remodeling of immune cells was dependent on both the number and phenotype of the MPs.
Conclusions:
- Elevated MP levels and their functional remodeling effects in PLWH may impede effective control of chronic infections.
- This MP-driven immune dysregulation could contribute to chronic immune activation and the development of comorbid diseases.
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