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    We developed a novel label-free cell imaging technique using a photonic crystal nanolaser array. This method achieves high refractive index resolution, enabling detailed visualization of cell attachment conditions.

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    Area of Science:

    • Photonics
    • Biomedical Imaging
    • Nanotechnology

    Background:

    • Label-free imaging is crucial for observing live cells without perturbation.
    • Photonic crystal nanolasers offer potential for miniaturized and sensitive optical sensing.
    • Existing methods often lack the resolution or non-invasive nature required for detailed cellular analysis.

    Purpose of the Study:

    • To demonstrate a label-free imaging method for living cells using a photonic crystal nanolaser array.
    • To achieve high refractive index resolution for improved imaging capabilities.
    • To visualize cell attachment conditions non-invasively.

    Main Methods:

    • Fabrication of a GaInAsP H0-type photonic crystal nanolaser array with 441 integrated nanolasers.
    • Photopumping the nanolaser array to achieve 100% lasing yield.
    • Attaching HeLa cells to the array and measuring nanolaser wavelength shifts as pixel information.
    • Incorporating nanoslots and compensating for index sensitivity nonuniformity.

    Main Results:

    • Successful acquisition of cell images based on nanolaser wavelength shifts.
    • Images partially corresponded to optical micrographs, reflecting cell attachment.
    • Achieved a significant improvement in refractive index resolution from ~10(-2) to 2 × 10(-3).

    Conclusions:

    • The proposed label-free imaging method using a nanolaser array is effective for visualizing living cells.
    • The enhanced resolution allows for more detailed analysis of cellular properties and interactions.
    • This technique holds promise for advanced live-cell imaging and diagnostics.