Living-cell imaging using a photonic crystal nanolaser array

We proposed and demonstrated a label-free imaging method for living cells using a GaInAsP H0-type photonic crystal nanolaser array. We integrated 441 nanolasers in an arrayed configuration and achieved photopumped lasing with a 100% yield. Then, we attached HeLa cells on it, measured the wavelengths of all nanolasers and used them as pixel information. We acquired cell images, which partially corresponds to optical micrographs and probably reflects the attachment condition of the cells. We improved the refractive index resolution from ~10(-2) to 2 × 10(-3) by incorporating a nanoslot into each nanolaser and compensating the nonuniformity of each index sensitivity.