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Multi-channel SPR biosensor based on PCF for multi-analyte sensing applications.

R Otupiri, E K Akowuah, S Haxha

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    Summary
    This summary is machine-generated.

    This study introduces a novel photonic crystal fiber (PCF) biosensor for multi-analyte detection using surface plasmon resonance (SPR). Its unique design allows for both multi-analyte sensing and self-referencing capabilities.

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    Area of Science:

    • Photonics
    • Nanotechnology
    • Biomedical Engineering

    Background:

    • Surface Plasmon Resonance (SPR) is a powerful label-free optical sensing technique.
    • Photonic Crystal Fibers (PCFs) offer unique light-confining properties for integrated sensing.
    • Developing multi-channel biosensors is crucial for simultaneous detection of multiple analytes.

    Purpose of the Study:

    • To theoretically investigate a novel multi-channel PCF-based SPR biosensor.
    • To explore its potential for multi-analyte sensing and self-referencing.
    • To analyze the sensing performance using advanced numerical methods.

    Main Methods:

    • Theoretical investigation using Finite Element Method (FEM) and Perfectly Matching Layers (PML).
    • Design of a PCF with gold-coated microfluidic channels and elliptical air holes.
    • Analysis of loss spectra, dispersion, and detection capabilities for fundamental modes.

    Main Results:

    • The proposed PCF biosensor design enables dual operation modes: multi-analyte sensing and self-referencing.
    • Detailed analysis of loss spectra and dispersion characteristics for HE(11)(x) and HE(11)(y) modes.
    • Demonstrated potential for high detection capabilities in biosensing applications.

    Conclusions:

    • The novel PCF-SPR biosensor design shows significant promise for advanced bio-sensing.
    • The integrated multi-channel and self-referencing capabilities enhance its practical utility.
    • FEM simulations provide a robust framework for optimizing PCF biosensor performance.