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Related Concept Videos

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

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Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
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Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

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Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

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In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
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The Effect of Aging on Tissues01:19

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
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Protein and Older Persons.

Juergen M Bauer1, Rebecca Diekmann1

  • 1Department of Geriatric Medicine, Carl von Ossietzky Universität Oldenburg, Klinikum Oldenburg gGmbH, Rahel-Straus-Street 10, 26133 Oldenburg, Germany.

Clinics in Geriatric Medicine
|July 22, 2015
PubMed
Summary
This summary is machine-generated.

Optimal protein intake is crucial for older adults to maintain muscle mass and function. Current recommendations suggest 1.0-1.2 g/kg body weight daily, with higher amounts potentially needed for specific health conditions.

Keywords:
Amino acidsOlder personsProteinRequirementsSupplementation

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Area of Science:

  • Gerontology
  • Nutritional Science
  • Muscle Physiology

Background:

  • Adequate protein intake is essential for preserving muscle mass, functionality, and quality of life in aging populations.
  • Recent scientific literature has led to updated recommendations for protein consumption in older adults.

Purpose of the Study:

  • To review and present current recommendations for optimal protein intake in older persons.
  • To discuss factors beyond total daily intake, including distribution and protein quality.

Main Methods:

  • Literature review of recent scientific publications on protein requirements in older adults.
  • Synthesis of evidence-based recommendations for protein intake.

Main Results:

  • Healthy older adults are recommended to consume 1.0 to 1.2 grams of protein per kilogram of body weight per day (g/kg BW/d).
  • Higher protein intake (>1.2 g/kg BW/d) may be necessary for older individuals with certain disease states.
  • Consideration of protein distribution throughout the day, per-meal amounts, and amino acid profiles is important.

Conclusions:

  • The optimal protein intake for older adults is critical for maintaining health and function.
  • Current guidelines recommend 1.0-1.2 g/kg BW/d for healthy older individuals, with adjustments for disease.
  • Factors like protein timing and quality also play a significant role in optimizing protein utilization.