[The structural bases of liver cell aging and age-related characteristics of their reactivity]
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Updated: Jul 19, 2026

A Standardized Method for the Analysis of Liver Sinusoidal Endothelial Cells and Their Fenestrations by Scanning Electron Microscopy
Published on: April 30, 2015
Abstract:
The liver of the 8-, 24-, 30- and 38-month-old Wistar male rats were studied morphometrically in the light and electron microscope under normal conditions and after bleeding and enterosorption. Under both conditions--ageing and bleeding--the hepatocyte death (apoptosis and colliquative necrosis) occurs resulting from the progression of granular and hydropic degeneration. Apoptosis develops mainly in the 1st zone and necrosis in the 3rd zone of the liver acinus this being due to the pattern of blood supply. The hepatocyte death through the apoptosis is followed by immunocompetent cell response. Compensatory processes in ageing are manifested in the hepatocyte hypertrophy this being due to the hyperplasia of cytoplasmatic structures, smooth cytoplasmic network particularly.
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