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Updated: Apr 6, 2026

Microfluidics in Assessing Platelet Function
Published on: November 8, 2024
Effect of substituted stilbenes on platelet function
Federica Messina1, Giuseppe Guglielmini2, Massimo Curini1
1Department of Pharmaceutical Sciences, Section of Public Health, University of Perugia, via del, Liceo, 1, 06123 Perugia, Italy.
Abstract:
Stilbenes, including resveratrol, are polyphenols provided with protective actions on the cardiovascular system. Some natural derivatives of resveratrol, like pterostilbene, have a better bioavailability than the parent compound. The aim of the present study was to prepare different substituted stilbenes (dimethylallyloxy-stilbene, dimethylallyloxy-pterostilbene) and compare them with resveratrol, p-hydroxy-stilbene and pterostilbene for their biologic activities on platelet aggregation, platelet radical oxygen species (ROS) production, and platelet nitric oxide (NO) synthesis. The results show that the increase of stilbene derivative lipophilicity enhances their biologic activities.
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