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lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

Epigenetic Regulation

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...

Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

Epigenetic Regulation

Epigenetic Regulation

General Transcription Factors

General Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...

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Related Experiment Video

Updated: Apr 6, 2026

Determining Genome-wide Transcript Decay Rates in Proliferating and Quiescent Human Fibroblasts

Determining Genome-wide Transcript Decay Rates in Proliferating and Quiescent Human Fibroblasts

Published on: January 2, 2018

Noncoding Transcriptional Landscape in Human Aging.

Marina C Costa¹, Ana Lúcia Leitão², Francisco J Enguita¹

¹Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av. Professor Egas Moniz, 1649-028, Lisbon, Portugal.

Current Topics in Microbiology and Immunology

|July 23, 2015

Summary

This summary is machine-generated.

Aging causes cellular dysfunction through epigenetic changes. This study explores how long noncoding RNAs (lncRNAs) may drive these age-associated gene expression patterns in human cells.

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Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome

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Last Updated: Apr 6, 2026

Determining Genome-wide Transcript Decay Rates in Proliferating and Quiescent Human Fibroblasts

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Published on: January 2, 2018

Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry

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Published on: April 6, 2022

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome

Published on: June 15, 2016

Area of Science:

Gerontology and Molecular Biology
Epigenetics and Gene Regulation

Background:

Aging is a universal biological process marked by physiological decline and increased disease risk.
Cellular aging correlates with functional decline in tissues like muscle, immune, and neuronal systems.
Age-related transcriptional changes are mediated by epigenetic mechanisms, but their impact on cellular epigenetic states is not fully understood.

Purpose of the Study:

To investigate the potential role of noncoding RNAs, particularly long noncoding RNAs (lncRNAs), in inducing age-associated gene expression profiles.
To analyze the functions of lncRNAs and other noncoding RNAs in regulating aging-related cellular pathways.

Main Methods:

Review and analysis of existing studies on noncoding RNAs and aging.
Examination of the regulatory roles of lncRNAs in gene expression.
Exploration of epigenetic mechanisms underlying age-associated transcriptional changes.

Main Results:

Noncoding RNAs can act as molecular signals regulating gene expression and epigenetic states.
lncRNAs may significantly influence the transcriptional landscape of aged human cells.
Further analysis is needed to fully elucidate the specific functions and pathways regulated by noncoding RNAs in aging.

Conclusions:

Noncoding RNAs, especially lncRNAs, are hypothesized to play a direct role in the epigenetic regulation of aging.
Understanding the role of lncRNAs in aging could provide insights into age-related cellular dysfunction and disease.