Related Experiment Video
Updated: Apr 6, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
Serological aggravation of autoimmune thyroid disease in two cases receiving nivolumab
Tomohiko Narita1, Naoki Oiso1, Yasunori Taketomo2
1Department of Dermatology, Kinki University Faculty of Medicine, Osaka-Sayama, Japan.
Abstract:
Nivolumab, a blockade of programmed cell death 1, is now administrated for advanced malignant melanomas. Nivolumab-associated adverse events include organ-specific autoimmune disorders; autoimmune thyroid disease, vitiligo and insulin-dependent diabetes. However, predisposed persons are currently unknown. Here, we report serological aggravation of autoimmune thyroid disease in two cases receiving nivolumab: one with Hashimoto disease and another with probable subclinical Hashimoto disease. We should verify if nivolumab-related hypothyroidism and hyperthyroidism are predisposed to occur in euthyroid individuals with subclinical autoimmune thyroid disease.
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