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Updated: Apr 6, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Benzoquinoline amines - Key intermediates for the synthesis of angular and linear dinaphthonaphthyridines
Kolandaivel Prabha1, K J Rajendra Prasad1
1Department of Chemistry, Bharathiar University, Coimbatore, Tamil Nadu, India.
Abstract:
A systematic study on the condensation reaction of 2,4-dichlorobenzo[h]quinoline and naphth-1-ylamine in the presence of CuI as catalyst to functionalised mono- and di-substituted (naphthalen-1-yl)benzo[h]quinoline amines was described. Subsequently these mono- and di-substituted amines on polyphosphoric acid catalysed cyclisation reaction with aromatic/heteroaromatic carboxylic acids led to the construction of angular and linear aromatic/heteroaromatic substituted dinaphthonaphthyridines in good yields.
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