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Treatment of Sandifer Syndrome with an Amino-Acid-Based Formula
Natasha Bamji1, Stuart Berezin1, Howard Bostwick1
1Department of Pediatrics, Division of Pediatric Gastroenterology and Nutrition, New York Medical College, Valhalla, New York.
Insights
Sandifer syndrome (SS) in infants can be refractory to standard treatments. A hypoallergenic formula effectively treated two infants with refractory SS, suggesting milk protein allergy as a potential cause.
Area of Science:
- Pediatrics
- Gastroenterology
- Allergy
Background:
- Sandifer syndrome (SS) is characterized by gastrointestinal dysfunction and abnormal posturing.
- Refractory cases of SS pose a diagnostic and therapeutic challenge in infants.
- Conventional antireflux treatments are often ineffective in certain SS presentations.
Abstract:
Objective To study the presentation and treatment in two infants who presented with refractory Sandifer syndrome (SS). Study Design We retrospectively reviewed the cases of two infants who presented to our outpatient clinic with SS who were refractory to conventional treatment. Results We report two patients with refractory SS who responded to treatment with hypoallergenic formula. Conclusion It is important to consider a diagnosis of milk protein allergy responsive to hypoallergenic formula in patients with SS who are refractory to conventional antireflux treatment.
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