Related Experiment Video
Updated: Apr 6, 2026
07:42
An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract
Published on: July 1, 2020
6.0K
TUBERCULOSIS INFECTION MIGHT INCREASE THE RISK OF INVASIVE CANDIDIASIS IN AN IMMUNOCOMPETENT PATIENT
Xiao-Hua Chen1, Yun-Chao Gao2, Yi Zhang1
1Department of Infectious Diseases, Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, China.
Revista Do Instituto De Medicina Tropical De Sao Paulo
|July 23, 2015
Summary
A rare case of deep Candida infection and spinal tuberculosis coinfection occurred in a healthy young man. Tuberculosis may weaken immunity, increasing invasive candidiasis risk even in immunocompetent individuals.
Area of Science:
- Infectious Diseases
- Mycology
- Immunology
Background:
- Deep Candida infections typically affect immunocompromised individuals.
- Invasive candidiasis presents a significant challenge in clinical settings.
Observation:
- A healthy 19-year-old male presented with prolonged fever and lower back pain.
- He had a history of scalded mouth syndrome.
- Coinfection with Candida albicans and Mycobacterium tuberculosis was diagnosed.
Findings:
- The patient exhibited multiple deep organ involvement.
- Culture of aspirates confirmed both fungal and bacterial pathogens.
- Antifungal and antituberculous therapies led to significant symptom improvement.
Implications:
- This case highlights that tuberculosis can compromise immune defenses in immunocompetent hosts.
- Tuberculosis may predispose individuals to invasive candidiasis.
- Clinicians should consider invasive fungal infections in patients with tuberculosis, regardless of immune status.
Related Concept Videos
01:29Pulmonary Tuberculosis I
1.5K
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
1.5K
01:26Factors Affecting the Risk of Infection
14.6K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
14.6K
01:28Pulmonary Tuberculosis II
2.2K
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
2.2K
01:28Pulmonary Tuberculosis V
888
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
888
01:26Pulmonary Tuberculosis IV
728
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
728
01:25Transmission-based Precautions II: Airborne and Protective Environment
2.2K
Transmission-based precautions are for patients infected or suspected to be infected (or colonized) with organisms posing a significant risk to others. The transmission precautions include airborne and protective environment precautions.
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
2.2K