Related Experiment Video

Updated: Apr 6, 2026

Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix
10:37

Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix

Published on: October 20, 2021

3.5K

Naturally occurring core immune-escape and carboxy-terminal mutations\truncations in patients with e antigen negative

Ranjit Chauhan1,2, Shiv K Sarin3, Manoj Kumar1

  • 1Department of Gastroenterology and Advanced Centre for Liver Diseases, G.B. Pant Hospital, Room No. 201, New Delhi, 110002, India.

Hepatology International
|July 24, 2015
PubMed

Insights

Core immune escape mutations are more prevalent in decompensated liver disease patients with hepatitis B e antigen negative chronic hepatitis B (HBeAg -ve CHB). These mutations may contribute to disease severity in HBeAg -ve CHB.

Area of Science:

  • Hepatology
  • Virology
  • Genetics

Background:

  • Hepatocellular injury in HBeAg -ve CHB is often progressive.
  • Limited data exists on core mutations and liver disease severity in HBeAg -ve CHB.

Purpose of the Study:

  • To investigate the association between core mutations and liver disease severity in HBeAg -ve CHB patients.

Main Methods:

  • Sequencing and analysis of precore and core regions in 118 HBeAg -ve CHB patients.
  • Detection of precore, T helper, CTL, B-cell epitope, and core mutations.

Main Results:

  • HBV genotype D was predominant (81%).
  • Core immune escape mutations were found in 52% of patients.
  • Specific mutations (cT12S, cS21T, cE77D) were higher in patients with precore stop codon mutations.
  • Several core immune escape mutations (cT12S, cS21T, cT67P/N, cE113D, cP130T/Q) were significantly higher in decompensated patients.

Conclusions:

  • Core immune-escape mutations cT12S, cS21T, cT67P, cE113D, and cP130T/Q are more frequent in decompensated liver disease.
  • These mutations may influence liver disease severity in HBeAg -ve CHB.
Abstract

Keywords:
Carboxy-terminalCoreGenotypeHBVHBeAgImmune-escapeMutation

More Related Videos

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice07:25

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice

Published on: September 25, 2019

7.5K
Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation12:09

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation

Published on: February 28, 2019

10.4K

Related Concept Videos

Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver.
42
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
1.9K
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
8.3K
Viral Mutations00:36

Viral Mutations

A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
40.8K
Viruses with RNA Genomes01:29

Viruses with RNA Genomes

RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...
1.4K
Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
2.1K