Related Experiment Video
Updated: Apr 6, 2026

An In Ovo Model for Testing Insulin-mimetic Compounds
Published on: April 23, 2018
Recent Advances in Synthetic Chemistry of Diabetic Research
Sreekanth Thota1, Carlos M Morel
1National Institute for Science and Technology on Innovation on Neglected Diseases, Center for Technological Development in Health, Oswaldo Cruz Foundation (Fiocruz), Av. Brazil 4036, Manguinhos, 21040-361 - Rio de Janeiro - RJ - Brazil. sthota@cdts.fiocruz.br.
Abstract:
Diseases started even before the existence of human beings. Therefore, when the civilization began, the biggest threats for human were diseases. Man has made several sincere attempts for the search of new drugs in order to cure and control different diseases. Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder that accounts for about 85-95% of all diagnosed cases of diabetes. It is characterized by abnormalities in glucose homeostasis in many organs, and is associated with considerable morbidity and mortality. Extensive research has been carried out using rational drug design to identify and optimize new leads for molecular targets of T2DM, which include Heterocyclic compounds, metal complexes, H3 receptor antagonists, glucagon receptor antagonists and human incretin-degrading enzyme dipeptidyl peptidase IV inhibitors.
Related Concept Videos
Insulin: Biosynthesis, Chemistry, and Preparation
Damage or functional impairment of β-cells inhibits insulin production, leading to diabetes. Diabetes treatment...
Glucagon-like Receptor Agonists
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
Production of Pharmaceuticals
Synthetic Biology
Golden rice
Golden rice is a genetically modified...
Diabetes: Management and Pharmacotherapy
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Diabetes Mellitus: Overview and Type I Subtype
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...

