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Updated: Apr 6, 2026

Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers

Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers

Published on: September 19, 2022

A Pathway Toward Tumor Cell-Selective CPPs?

Isabel D Alves¹, Manon Carré, Solange Lavielle

¹Institute of Chemistry & Biology of Membranes & Nanoobjects (UMR5248 CBMN), CNRS, Institut Polytechnique Bordeaux, Universite Bordeaux, All. Geoffroy Saint-Hilaire, 33600, Pessac, France, i.alves@cbmn.u-bordeaux.fr.

Methods in Molecular Biology (Clifton, N.J.)

|July 24, 2015

Summary

This summary is machine-generated.

Cell-penetrating peptides (CPPs) can be engineered for cancer cell targeting. Exploiting the enhanced anionic character of tumor cell membranes could improve CPP selectivity for cancer therapy.

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Area of Science:

Biochemistry
Molecular Biology
Cancer Research

Background:

Cell-penetrating peptides (CPPs) show promise for drug delivery and diagnostics.
A major limitation of CPPs is their lack of cell-type specificity.
CPPs interact with cell membranes via electrostatic forces with anionic components.

Purpose of the Study:

To explore strategies for enhancing CPP selectivity towards cancer cells.
To leverage the unique membrane properties of tumor cells for targeted delivery.

Main Methods:

Review of existing literature on CPP-cell membrane interactions.
Analysis of the role of electrostatic interactions in CPP uptake.
Examination of differences in membrane composition between cancer and healthy cells.

Main Results:

Tumor cells exhibit overexpression of cell surface glycosaminoglycans.
Cancer cell membranes possess a higher proportion of anionic lipids in their outer leaflet.
These features result in an increased overall anionic character of tumor cell membranes.

Conclusions:

The enhanced anionic nature of cancer cell membranes can be exploited for CPP targeting.
This approach offers a potential strategy to improve CPP selectivity for cancer cells.
Further research into CPP design based on these membrane properties is warranted.