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Adolescent Scalp Psoriasis: Update on Topical Combination Therapy
Emily Osier1, Barbara Gomez2, Lawrence F Eichenfield1
1Division of Pediatric and Adolescent Dermatology, University of California, San Diego, California; Rady Children's Hospital, San Diego, California;
The Journal of Clinical and Aesthetic Dermatology
|July 24, 2015
Summary
Topical vitamin D analog and steroid combinations offer improved effectiveness and tolerability for pediatric plaque psoriasis. Once-daily application of calcipotriene/betamethasone dipropionate suspension is safe and effective for adolescents.
Area of Science:
- Dermatology
- Pediatric Dermatology
- Pharmacology
Background:
- Plaque psoriasis often manifests in childhood, significantly impacting patients' quality of life.
- Topical therapies are the standard first-line treatment for plaque psoriasis.
- Fixed-combination topical formulations of vitamin D analogs and corticosteroids demonstrate synergistic benefits over monotherapy.
Purpose of the Study:
- To evaluate the safety and effectiveness of a once-daily calcipotriene/betamethasone dipropionate topical suspension in pediatric patients.
- To assess the treatment in adolescents aged 12 to 17 years with scalp plaque psoriasis.
Main Methods:
- Established safety and effectiveness of a fixed-combination topical suspension (calcipotriene/betamethasone dipropionate).
- Administered once daily to pediatric patients (12-17 years) with scalp plaque psoriasis.
- Focused on evaluating outcomes in the specified pediatric demographic.
Main Results:
- The once-daily calcipotriene/betamethasone dipropionate topical suspension demonstrated established safety and effectiveness.
- Treatment was specifically validated in children aged 12 to 17 years suffering from scalp plaque psoriasis.
- Combination therapies and once-daily dosing simplify treatment regimens, potentially improving patient adherence.
Conclusions:
- A once-daily topical suspension of calcipotriene/betamethasone dipropionate is a safe and effective option for adolescent scalp plaque psoriasis.
- Fixed-combination topical agents offer enhanced efficacy and tolerability compared to individual components.
- Simplifying treatment regimens and accommodating vehicle preferences can improve adherence and real-world effectiveness in pediatric psoriasis management.
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