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Imaging Nigrostriatal Dopaminergic Deficit in Holmes Tremor with 18F-PR04.MZ-PET/CT
Carlos Juri1, Pedro Chana, Vasko Kramer
1From the *Department of Neurology, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile; †Department of Neurology, Hospital Sotero del Río, Santiago, Chile; ‡Department of Neurology, Universidad de Santiago de Chile, Santiago, Chile; §Nuclear Medicine and PET/CT Center FALP, Santiago,Chile; ¶Department of Chemistry, University of Oslo, Oslo, Norway; and ∥Institute of Nuclear Chemistry, Johannes Gutenberg-University, Mainz, Germany.
Abstract:
Holmes tremor is an infrequent clinical syndrome characterized by unilateral rest, postural, and action tremor often secondary to a brain lesion. We herein report an interesting case of Holmes tremor studied with PET and F-PR04.MZ, a new high-affinity radioligand for dopamine transporters, currently under investigation at our center. F-PR04.MZ-PET can be useful to study the integrity of the nigrostriatal dopaminergic system to improve diagnosis and therapeutic outcome in patients with Holmes tremor and Parkinson disease.
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