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Related Experiment Video

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Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

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Fast Simulation of Mechanical Heterogeneity in the Electrically Asynchronous Heart Using the MultiPatch Module.

John Walmsley¹, Theo Arts¹, Nicolas Derval²

¹Department of Biomedical Engineering, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands.

Plos Computational Biology

|July 24, 2015

Summary

A new MultiPatch module for the CircAdapt model simulates cardiac electrical asynchrony and mechanical dyssynchrony. This computational tool accurately predicts myocardial deformation, highlighting activation time

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Last Updated: Apr 6, 2026

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Area of Science:

Computational modeling
Cardiovascular physiology
Biomedical engineering

Background:

Cardiac electrical asynchrony, from pacing or conditions like left bundle-branch block (LBBB), causes detrimental myocardial contraction heterogeneity.
Current finite element method simulations for cardiac mechanical dyssynchrony are computationally intensive, limiting clinical use.
Patient-specific models are crucial for understanding and treating cardiac dysfunction.

Purpose of the Study:

To present the MultiPatch module, an alternative computational approach for simulating cardiac mechanical dyssynchrony.
To test the hypothesis that activation time is more critical than tissue location in determining myocardial deformation during asynchronous heartbeats.
To validate the MultiPatch module's accuracy against experimental and patient data.

Main Methods:

Developed the MultiPatch module, subdividing cardiac walls into patches within the CircAdapt lumped-parameter model.
Simulated myocardial deformation in response to ventricular pacing and in a patient with LBBB and heart failure.
Utilized endocardial recordings, wall volumes, and tagged MRI data for model validation.

Main Results:

Simulations showed qualitative and quantitative agreement with experimental strain patterns, including shortening and rebound stretch.
Model fiber strain closely matched experimental circumferential strain.
Patient-specific simulations demonstrated qualitative agreement with observed circumferential strain patterns.

Conclusions:

The MultiPatch module generates realistic regional deformation patterns in asynchronous hearts.
Myocardial deformation is primarily influenced by activation time rather than tissue location within a cardiac wall.
The CircAdapt model with the MultiPatch module enables fast, realistic simulations of dyssynchronous myocardial deformation within a closed-loop cardiovascular system.