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Related Concept Videos

Hypersensitivity Reactions: Delayed Hypersensitivity Reactions01:29

Hypersensitivity Reactions: Delayed Hypersensitivity Reactions

217
Delayed-Type Hypersensitivity (DTH), or Type IV hypersensitivity, is a cell-mediated immune response. It occurs when T cells, rather than antibodies, mediate a reaction to specific antigens. It is characterized by a delayed onset (1-2 days) and involves the recruitment of macrophages to the inflammation site.The initiation of a DTH response begins with the sensitization of T cells. During this phase, which lasts at least 1-2 weeks, antigen-specific T cells are activated, clonally expanded, and...
217
Hypersensitivity Reactions: Immune-Complex Reactions01:19

Hypersensitivity Reactions: Immune-Complex Reactions

175
Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum...
175

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Updated: Apr 6, 2026

Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis
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Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis

Published on: May 23, 2021

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Delayed hypersensitivity reaction after cervical disc replacement: a case report.

M Lagier1, M Briere1, H Giorgi1

  • 1Unité de chirurgie du Rachis, CHU Timone, 264, rue Saint-Pierre, 13385 Marseille cedex 5, France.

Orthopaedics & Traumatology, Surgery & Research : OTSR
|July 25, 2015
PubMed
Summary
This summary is machine-generated.

A delayed allergic reaction to a cervical disc prosthesis caused a patient

Keywords:
AllergyDelayed hypersensitivityRashTotal disc arthroplasty

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Area of Science:

  • Orthopedic Surgery
  • Allergy Immunology

Background:

  • Cervical disc arthroplasty utilizes metal prostheses.
  • Allergic reactions to implants are rare but possible.

Observation:

  • A patient experienced recurrent neck pain, rash, and dysphagia post-arthroplasty.
  • A cobalt-chromium-molybdenum disc prosthesis was implanted two years prior.

Findings:

  • Allergy testing confirmed a type-4 hypersensitivity reaction to chromium.
  • Surgical removal of the prosthesis and subsequent fusion resolved symptoms.

Implications:

  • Delayed allergic reactions to spinal implants are uncommon.
  • Consider implant allergy in recurrent symptoms with non-spinal signs.