Hydrazones as a privileged structural linker in antitubercular agents: a review
Bijo Mathew1, Jerad Suresh, Mohamed J Ahsan
1Division of Drug Design and Medicinal Chemistry Research Lab, Department of Pharmaceutical Chemistry, Grace; College of Pharmacy, Palakkad-678004, Kerala, India. bijovilaventgu@gmail.com.
Infectious Disorders Drug Targets
|July 25, 2015
Abstract:
Hydrazones are a versatile linker of connecting various classes of organic compounds with a unique structural feature of hydrogen bonding donor and the hydrogen bonding acceptor region. An extensive number of research has been carried out on hydrazone derivatives as a potent class of antitubercular agents. The present review focuses on the chemistry, antitubercular activity and structure activity relationship (SAR) of diverse classes of phenyl and heterocyclic based hydrazones.
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