Antimicrobial Pharmacokinetics and Pharmacodynamics
Andrew S Jarrell1, Rachel M Kruer1, Dachelle Johnson1
11 Department of Pharmacy, The Johns Hopkins Hospital , Baltimore, Maryland.
Surgical Infections
|July 25, 2015
Summary
Optimizing antimicrobial drug use by considering pharmacokinetic and pharmacodynamic properties can improve patient outcomes. This approach helps minimize adverse effects and combat antimicrobial resistance.
Area of Science:
- Pharmacology
- Infectious Diseases
- Clinical Pharmacy
Background:
- Antimicrobial medications are crucial but can cause adverse effects and resistance, especially with improper use.
- Understanding drug properties is key to optimizing antimicrobial therapy.
- Pharmacokinetic and pharmacodynamic principles guide appropriate antimicrobial drug use.
Purpose of the Study:
- To review the literature on pharmacokinetic and pharmacodynamic principles in antimicrobial therapy.
- To emphasize the importance of optimizing antimicrobial dosing for better patient outcomes.
Main Methods:
- A review of the English-language scientific literature was conducted.
Main Results:
- Pharmacokinetic (absorption, distribution, metabolism, elimination) and pharmacodynamic properties influence drug efficacy at the infection site.
- Optimal dosing based on these properties improves clinical outcomes.
- In surgical patients, altered drug distribution and elimination necessitate careful dosing considerations.
- Appropriate antimicrobial use can reduce adverse drug effects and the development of antimicrobial resistance.
Conclusions:
- Tailoring antimicrobial selection and dosage to pharmacokinetic and pharmacodynamic profiles can enhance patient outcomes.
- Consideration of these drug properties is essential for effective antimicrobial stewardship.
- Optimized antimicrobial therapy may lead to fewer adverse events and reduced resistance.
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