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Updated: Apr 6, 2026

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Iron-catalyzed direct α-arylation of ethers with azoles
Arkaitz Correa1, Béla Fiser, Enrique Gómez-Bengoa
1Department of Organic Chemistry I, University of the Basque Country (UPV/EHU), Joxe Mari Korta R&D Center, Avda. Tolosa 72, 20018 Donostia-San Sebastión, Spain. arkaitz.correa@ehu.es.
Abstract:
The direct α-arylation of cyclic and acyclic ethers with azoles has been achieved, which features a novel iron-catalyzed cross-dehydrogenative coupling (CDC) process. This practical oxidative method allowed the efficient C2-alkylation of a variety of (benzo)azoles constituting straightforward access to heterocycles of utmost medicinal significance and highlighting the convenient use of feedstock substrates and iron catalysts. A preliminary mechanism supported by DFT calculations is discussed as well.
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