Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stem Cell Niche01:26

Stem Cell Niche

6.6K
The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
6.6K
Multipotency and Niche of Bulge Stem Cell01:06

Multipotency and Niche of Bulge Stem Cell

4.4K
A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
4.4K
Zygotic Development And Stem Cell Formation01:10

Zygotic Development And Stem Cell Formation

7.5K
The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...
7.5K
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

4.1K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
4.1K
Adult Stem Cells01:33

Adult Stem Cells

34.5K
Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
34.5K
Stem Cell Culture01:17

Stem Cell Culture

6.6K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
6.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mechanical regulation of immunity in metastasis.

Nature materials·2026
Same author

Mavacamten shows broad benefit in human and mouse models of MYBPC3-related hypertrophic cardiomyopathy.

Nature cardiovascular research·2026
Same author

Therapeutic Poxviruses Induce the Secretion of Immunostimulating and Anti-Tumoral Extracellular Vesicles.

Journal of extracellular vesicles·2026
Same author

The heart beats cancer.

Trends in cancer·2026
Same author

Divergent granulopoiesis at extramedullary sites safeguards antibacterial host defense.

Science immunology·2026
Same author

[When organelle positioning drives tumor progression].

Medecine sciences : M/S·2026

Related Experiment Video

Updated: Apr 6, 2026

Author Spotlight: Advancing Organoid Generation for Drug Development Using iPSCs
06:38

Author Spotlight: Advancing Organoid Generation for Drug Development Using iPSCs

Published on: March 15, 2024

2.4K

Multicellular cuddling in a stem cell niche.

Andrés Hidalgo1, Jacky G Goetz

  • 1a Fundación CNIC; Madrid, Spain and Institute for Cardiovascular Prevention, LMU ; Munich , Germany.

Cell Adhesion & Migration
|July 25, 2015
PubMed
Summary
This summary is machine-generated.

Haematopoietic stem and progenitor cells (HSPCs) sustain blood systems by colonizing niches. Zebrafish studies reveal endothelium remodeling, or "cuddling," in perivascular niches promotes HSPC expansion.

Keywords:
bloodbone marrowextravasationhaematopoietic stem cellvascular niche

More Related Videos

Flow Cytometry Analysis of Murine Bone Marrow Hematopoietic Stem and Progenitor Cells and Stromal Niche Cells
08:34

Flow Cytometry Analysis of Murine Bone Marrow Hematopoietic Stem and Progenitor Cells and Stromal Niche Cells

Published on: September 28, 2022

6.2K
Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes
10:48

Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes

Published on: April 12, 2015

10.7K

Related Experiment Videos

Last Updated: Apr 6, 2026

Author Spotlight: Advancing Organoid Generation for Drug Development Using iPSCs
06:38

Author Spotlight: Advancing Organoid Generation for Drug Development Using iPSCs

Published on: March 15, 2024

2.4K
Flow Cytometry Analysis of Murine Bone Marrow Hematopoietic Stem and Progenitor Cells and Stromal Niche Cells
08:34

Flow Cytometry Analysis of Murine Bone Marrow Hematopoietic Stem and Progenitor Cells and Stromal Niche Cells

Published on: September 28, 2022

6.2K
Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes
10:48

Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes

Published on: April 12, 2015

10.7K

Area of Science:

  • Developmental biology
  • Hematopoiesis
  • Stem cell biology

Background:

  • Haematopoietic stem and progenitor cells (HSPCs) are crucial for lifelong blood system maintenance through self-renewal and differentiation.
  • HSPCs are known to migrate through intermediate niches before reaching the adult bone marrow.
  • Previous research characterized HSPC development but lacked understanding of perivascular niche roles in HSPC expansion.

Discussion:

  • The study investigates how perivascular niches support HSPC colonization and expansion.
  • Endothelium remodeling, termed "cuddling," is identified as a key mechanism within these niches.
  • The zebrafish embryo model offers unique advantages for studying these dynamic processes.

Key Insights:

  • Endothelium remodeling in perivascular niches, described as "cuddling," actively facilitates HSPC colonization.
  • This "cuddling" process is essential for sustaining HSPC expansion within the niche.
  • The findings provide novel insights into the microenvironmental regulation of hematopoietic stem cells.

Outlook:

  • Further research can explore the molecular signals involved in endothelium remodeling and HSPC interaction.
  • Understanding these niche dynamics may lead to therapeutic strategies for blood disorders.
  • Comparative studies in other models could validate the generalizability of these findings.