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Related Concept Videos

What is Cancer?02:12

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...
What is Cancer?02:12

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Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Overview of the Heart01:07

Overview of the Heart

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The Cardiac Cycle01:13

The Cardiac Cycle

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Adaptive Mechanisms in Cancer Cells

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Related Experiment Video

Updated: Jun 21, 2026

Chick Heart Invasion Assay for Testing the Invasiveness of Cancer Cells and the Activity of Potentially Anti-invasive Compounds
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Published on: June 6, 2015

The heart beats cancer.

Jacky G Goetz1

  • 1Tumor Biomechanics Lab, Strasbourg, France; Inserm UMR_S1109, Strasbourg, France; Université de Strasbourg, Strasbourg, France; Fédération de Médecine Translationnelle de Strasbourg (FMTS), Strasbourg, France; Equipe Labellisée Ligue Contre le Cancer, Strasbourg, France.

Trends in Cancer
|June 19, 2026
PubMed
Summary

Mechanical load from a beating heart suppresses cardiac cancer growth. This process involves Nesprin-2-dependent mechanotransduction, altering gene activity to reduce tumor cell proliferation.

Keywords:
cancerheartmechanical loading

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Area of Science:

  • Cardiovascular Biology
  • Cancer Mechanobiology
  • Epigenetics

Background:

  • Heart cancer is extremely rare despite the heart's high vascularization.
  • The mechanical forces exerted by the beating heart are significant.
  • Understanding how the heart microenvironment influences cancer is crucial.

Purpose of the Study:

  • To investigate the role of mechanical load in suppressing cardiac cancer growth.
  • To elucidate the molecular mechanisms underlying heart's anti-cancer effects.

Main Methods:

  • Studied cancer growth in the context of mechanical cardiac load.
  • Investigated Nesprin-2-dependent mechanotransduction pathways.
  • Analyzed changes in histone methylation and chromatin compaction.

Main Results:

  • Mechanical load in the beating heart significantly suppresses cancer growth.
  • Nesprin-2-dependent mechanotransduction mediates this suppression.
  • Changes in histone methylation and chromatin compaction reduce proliferation gene activity in cardiac tumor cells.

Conclusions:

  • The mechanical environment of the heart can act as a barrier to cancer progression.
  • Nesprin-2 and mechanotransduction are key regulators of cardiac tumor suppression.
  • Targeting these pathways could offer novel therapeutic strategies for cardiac tumors.