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Updated: Apr 6, 2026

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Published on: August 21, 2021
Histone lysine demethylases in Drosophila melanogaster
Andreana Holowatyj1, Zeng-Quan Yang, Lori A Pile
1a Department of Oncology ; Wayne State University School of Medicine ; Detroit , MI USA.
Abstract:
Epigenetic regulation of chromatin structure is a fundamental process for eukaryotes. Regulators include DNA methylation, microRNAs and chromatin modifications. Within the chromatin modifiers, one class of enzymes that can functionally bind and modify chromatin, through the removal of methyl marks, is the histone lysine demethylases. Here, we summarize the current findings of the 13 known histone lysine demethylases in Drosophila melanogaster, and discuss the critical role of these histone-modifying enzymes in the maintenance of genomic functions. Additionally, as histone demethylase dysregulation has been identified in cancer, we discuss the advantages for using Drosophila as a model system to study tumorigenesis.
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