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Localizing efficiency of [48V]vanadyl-pheophorbide in tumor as a new tumor imaging agent
1Laboratory of Nutrition, Faculty of Agriculture, Tohoku University, Sendai, Japan.
International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology
|January 1, 1989
Abstract:
[48V]vanadyl-pheophorbide (48V-Pheo) was synthesized by insertion of 48V into pheophorbide (Pheo), a decomposition product from chlorophyll. At 24 h after injection, 48V-Pheo showed a clearer image of an FM3A tumor than inorganic 48V. This agent also accumulated in MH 134 and S 180 tumors as well as in FM3A tumors. The imaging efficiency was dependent on the affinity of Pheo for tumors. 48V-Pheo seems to be suitable as a tumor imaging agent in conjunction with photodynamic therapy.