Related Experiment Video
Updated: Apr 6, 2026

High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles
Published on: July 6, 2012
An efficient continuous flow process for the synthesis of a non-conventional mixture of fructooligosaccharides
Paolo Zambelli1, Lucia Tamborini2, Samuele Cazzamalli2
1Department of Food Environmental and Nutritional Science (DeFENS), University of Milan, Via Mangiagalli, 20133 Milan, Italy.
Abstract:
A sustainable and scalable process for the production of a new mixture of fructooligosaccharides (FOS) was developed using a continuous-flow approach based on an immobilized whole cells-packed bed reactor. The technological transfer from a classical batch system to an innovative flow environment allowed a significant improvement of the productivity. Moreover, the stability of this production system was ascertained by up to 7 days of continuous working. These results suggest the suitability of the proposed method for a large-scale production of the desired FOS mixture, in view of a foreseeable use as a novel prebiotic preparation.
Related Concept Videos
Production of Organic Acids
Biosynthesis of Polysaccharides
Oligosaccharide Assembly
Multiple sugar molecules that may or may...
Glycolysis: Preparatory Phase
Upstream Processing
Batch vs Continuous Culture

