Related Experiment Video
Updated: Apr 6, 2026
05:48
Lung Fixation under Constant Pressure for Evaluation of Emphysema in Mice
Published on: September 26, 2019
10.0K
Emphysema: coiling up the lungs, trick or treat?
1Centre Of Respiratory Endoscopy and Laser‑theraphy A.O. Spedali Civili di Brescia, Brescia, Italy - michela.bezzi@spedalicivili.brescia.it.
Minerva Medica
|July 28, 2015
Summary
Lung volume reduction coil (LVRC) treatment shows significant clinical improvements for severe emphysema patients. This minimally-invasive approach offers a good safety profile with sustained results up to one year.
Area of Science:
- Pulmonology
- Interventional Pulmonology
- Medical Devices
Background:
- Advanced emphysema and hyperinflation significantly impair exercise capacity and pulmonary function.
- Bronchoscopic lung volume reduction (BLVR) techniques, including lung volume reduction coils (LVRC), are being investigated as less invasive alternatives to lung volume reduction surgery (LVRS).
Purpose of the Study:
- To investigate the feasibility, safety, and efficacy of LVRC treatment in a multi-center setting for patients with advanced emphysema.
- To evaluate the clinical outcomes and long-term results of LVRC treatment.
Main Methods:
- Multi-center clinical investigation of LVRC treatment.
- Assessment of exercise capacity, pulmonary function, safety, and long-term follow-up.
Main Results:
- LVRC treatment demonstrated significant clinical improvements in patients with severe emphysema in a multicenter analysis.
- The treatment exhibited a good safety profile and sustained positive results for up to one year.
- Literature suggests promising outcomes and an acceptable safety profile for endobronchial coils with increasing long-term data.
Conclusions:
- LVRC treatment appears to be a safe and effective option for improving clinical outcomes in severe emphysema patients.
- Further well-designed, controlled trials, including comparisons with LVRS, are necessary to recommend routine clinical use of endobronchial coils and BLVR.
- The field of BLVR, including endobronchial coils, shows promise but requires more robust evidence for widespread adoption.
Related Concept Videos
01:26Pneumothorax-I
2.0K
A pneumothorax is a condition where air builds up in the space between the lung and the chest wall, causing the lung to collapse. This condition arises when air enters the space between the parietal and visceral pleura, disrupting the negative pressure essential for lung inflation. This can lead to a partial or complete collapse of the lung.
Pneumothorax can be even further classified as spontaneous, traumatic, and tension pneumothorax.
Pneumothorax can be even further classified as spontaneous, traumatic, and tension pneumothorax.
2.0K
01:27Pneumothorax-II
1.5K
Pneumothorax is a medical condition defined by the buildup of air in the pleural space between the lungs and the chest wall. This accumulation of air can lead to partial or complete lung collapse, resulting in a range of clinical manifestations. Understanding the clinical presentation and effective management strategies is crucial for healthcare professionals in providing timely and appropriate care to individuals with pneumothorax.
Clinical Manifestations:
Clinical Manifestations:
1.5K
01:24Chronic Obstructive Pulmonary Disease
3.2K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
3.2K
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
5.1K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
5.1K
01:29Pulmonary Embolism I: Introduction
1.3K
Pulmonary embolism (PE) occurs when a thrombus, fat or air embolus, amniotic fluid, or tumor tissue blocks one or more pulmonary arteries. These blockages originate in the venous system or the right side of the heart.EtiologyPE primarily arises from deep vein thrombosis (DVT) and other hypercoagulable states, such as inherited thrombophilias. Additional etiological factors include venous stasis, commonly seen in obesity, and endothelial injury from surgery and trauma. Less common causes include...
1.3K
01:05Breathing
66.7K
The process of breathing, inhaling and exhaling, involves the coordinated movement of the chest wall, the lungs, and the muscles that move them. Two muscle groups with important roles in breathing are the diaphragm, located directly below the lungs, and the intercostal muscles, which lie between the ribs. When the diaphragm contracts, it moves downward, increasing the volume of the thoracic cavity and creating more room for the lungs to expand. When the intercostal muscles contract, the ribs...
66.7K