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Correction to Ward et al. (2015).

Ryan D Ward1, Vanessa Winiger1, Kerin K Higa1

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Motivation deficits impair cognitive performance in schizophrenia models. Enhancing motivation improved attention, suggesting it is crucial for functional gains in patients.

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Area of Science:

  • Neuroscience
  • Cognitive Science
  • Psychiatry

Context:

  • Interactions between motivation and cognition are crucial for daily functioning.
  • These interactions are not well understood at behavioral or neural levels.
  • Schizophrenia is associated with functional impairments and reduced quality of life.

Purpose:

  • To investigate the impact of motivation on cognitive performance in an animal model of schizophrenia.
  • To examine how altered D2 receptor activity affects the interplay between motivation and attention.
  • To determine if improving motivation can enhance cognitive function.

Summary:

  • A novel procedure tested sustained attention modulated by reward probability in mice.
  • Mice modeling schizophrenia (D2R-OE) showed impaired motivational modulation of attention.
  • This deficit was reversed by turning off the transgene, indicating a motivational basis.

Impact:

  • Deficits in motivation hinder the use of reward cues to guide attention.
  • Improving motivation can enhance cognitive performance and functional abilities.
  • Targeting motivational impairments is critical for treating cognitive and functional deficits in psychiatric patients.