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[Preparation of Curcumin Nanosuspensions and Its Pharmacokinetic Behavior in Rats]
Objective:
To prepare curcumin nanosuspensions (Cur-NS), and to study the pharmacokinetics of Cur-NS in rats.
Methods:
Cur-NS was prepared by the high pressure homogenization technology. The particle size, PdI and Zeta electric potential of nanosuspensions were taken as the indexes to determinate the factors that influenced the preparation process greatly. Curcumin concentrations in plasma were determined by HPLC and the pharmacokinetic parameters were calculated.
Results:
The particle size, polydisper- sion index, Zeta potential of Cur-NS were found to be 396. 4 ± 67. 2 nm, 0. 369 ± 0. 061 and -16.7 ± 3. 5 mV,respectively. AUC(0-t) of curcumin bulk drugs and Cur-NS were estimated to be 3. 62 ± 0. 66 mg/(L . h) and 14. 36 ± 1. 20 mg/( L . h), half lifes(t1/2) were 0. 62 ± 0. 06 h and 2. 15 ± 0. 15 h tmax were 1. 83 ± 0. 11 h and 1. 02 ± 0. 09 h, Cmax were 0. 94 ± 0.12 mg/L and 5. 78 ± 0. 46 mg/L, respectively.
Conclusion:
The pharmacokinetic results demonstrate that the curcumin bulk drugs prepared into Cur-NS can increase the drug's bioavailability in rats significantly.
