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Genome Annotation and Assembly

Genome Annotation and Assembly

The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.

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Related Experiment Video

Updated: Apr 6, 2026

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

Mouse genome annotation by the RefSeq project.

Kelly M McGarvey¹, Tamara Goldfarb¹, Eric Cox¹

¹National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD, 20894, USA.

Mammalian Genome : Official Journal of the International Mammalian Genome Society

|July 29, 2015

Summary

This summary is machine-generated.

Accurate mouse genome annotation is essential for research. The National Center for Biotechnology Information (NCBI) RefSeq database provides high-quality, continuously updated mouse genome annotation using a rigorous, multi-faceted approach.

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Area of Science:

Genomics
Bioinformatics
Molecular Biology

Background:

Accurate annotation of the mouse genome is crucial for advancing research using this model organism.
The National Center for Biotechnology Information (NCBI) provides essential resources for the mouse research community.

Purpose of the Study:

To highlight the key features and advantages of the NCBI RefSeq database for mouse genome annotation.
To provide an overview of the NCBI's processes for generating high-quality genome annotation data.

Main Methods:

Utilizing a combinatorial approach integrating computation, manual curation, and collaboration.
Focusing on the representation of full-length and non-redundant genomic data.
Implementing regular updates in response to new publications, nomenclature changes, and user feedback.

Main Results:

The RefSeq database offers high-quality annotation for multiple mouse genome assemblies.
Annotation products are rigorously curated, ensuring accuracy and completeness.
RefSeq records are regularly updated to reflect the latest scientific knowledge and community input.

Conclusions:

The NCBI RefSeq database is a vital resource for mouse genome research, providing reliable and up-to-date annotation.
The described annotation processes ensure the production of high-quality, non-redundant genomic data.
Understanding NCBI's resources and access methods can enhance research efficiency.