Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

10.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.6K
Cancer Therapies02:49

Cancer Therapies

3.0K
3.0K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

6.4K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
6.4K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

1.8K
1.8K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

9.1K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.1K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

3.9K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cost-utility of focused ultrasound compared to radiotherapy for Dutch patients with uncomplicated non-spinal bone metastases.

The European journal of health economics : HEPAC : health economics in prevention and care·2025
Same author

Patient Education and Communication in Palliative Radiotherapy: A Narrative Review.

Cancers·2025
Same author

Trident: Three-dimensional ray tracing for modeling high intensity focused ultrasound ablation.

The Journal of the Acoustical Society of America·2025
Same author

Interrater Agreement in Assessment of Eligibility for Magnetic Resonance-Guided High-Intensity Focused Ultrasound of Patients with Painful Bone Metastases.

Journal of vascular and interventional radiology : JVIR·2025
Same author

Mechanical HIFU and immune checkpoint inhibition: toward clinical implementation.

International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·2024
Same author

Focused Ultrasound: Noninvasive Image-Guided Therapy.

Investigative radiology·2024

Related Experiment Video

Updated: Apr 6, 2026

Electrochemotherapy of Tumours
03:57

Electrochemotherapy of Tumours

Published on: December 15, 2008

25.3K

Sonochemotherapy: from bench to bedside.

Bart H A Lammertink1, Clemens Bos1, Roel Deckers1

  • 1Image Guided Therapy, Imaging Division, University Medical Center Utrecht Utrecht, Netherlands.

Frontiers in Pharmacology
|July 29, 2015
PubMed
Summary
This summary is machine-generated.

Sonochemotherapy combines microbubbles and ultrasound for targeted drug delivery, enhancing drug uptake and enabling local release. This review covers its principles, methods, and clinical translation for cancer treatment.

Keywords:
chemotherapeutic drugdrug deliverymicrobubblesonochemotherapysonoporationultrasound

More Related Videos

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
09:19

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo

Published on: February 6, 2015

9.3K
Enrichment for Chemoresistant Ovarian Cancer Stem Cells from Human Cell Lines
11:50

Enrichment for Chemoresistant Ovarian Cancer Stem Cells from Human Cell Lines

Published on: September 10, 2014

14.0K

Related Experiment Videos

Last Updated: Apr 6, 2026

Electrochemotherapy of Tumours
03:57

Electrochemotherapy of Tumours

Published on: December 15, 2008

25.3K
Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
09:19

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo

Published on: February 6, 2015

9.3K
Enrichment for Chemoresistant Ovarian Cancer Stem Cells from Human Cell Lines
11:50

Enrichment for Chemoresistant Ovarian Cancer Stem Cells from Human Cell Lines

Published on: September 10, 2014

14.0K

Area of Science:

  • Biomedical Engineering
  • Pharmacology
  • Oncology

Background:

  • Microbubbles and ultrasound offer a promising approach for localized drug delivery.
  • Ultrasound activation of microbubbles induces bio-effects that enhance drug permeation and cellular uptake.
  • Drug-loaded microbubbles combine these effects with localized drug release upon destruction.

Purpose of the Study:

  • To review the fundamental principles of sonochemotherapy.
  • To discuss key aspects including microbubble types, administration routes, ultrasound parameters, and safety.
  • To explore the clinical translation and current status of sonochemotherapy.

Main Methods:

  • Review of existing literature on microbubble-ultrasound interactions for drug delivery.
  • Analysis of studies focusing on sonochemotherapy principles and applications.
  • Discussion of clinical trial data and safety considerations.

Main Results:

  • Sonochemotherapy enhances vascular and plasma membrane permeability for improved drug delivery.
  • Drug-loaded microbubbles facilitate localized drug release and cellular uptake.
  • The review details various parameters influencing sonochemotherapy efficacy and safety.

Conclusions:

  • Sonochemotherapy is a viable strategy for targeted drug delivery, particularly in chemotherapy.
  • Understanding the interplay of microbubbles, ultrasound, and drug properties is crucial for optimization.
  • Clinical translation is advancing, with initial studies showing promise for sonochemotherapy applications.