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Chronic Cerebrospinal Venous Insufficiency in Multiple Sclerosis: A Failed Concept
Nathan Kugler1, Parag J Patel2, Cheong Jun Lee1
1Division of Vascular Surgery, Medical College of Wisconsin, Milwaukee, WI.
Vascular Specialist International
|July 29, 2015
Summary
Chronic cerebrospinal venous insufficiency may contribute to multiple sclerosis. This review examines evidence for this link and treatments like venous angioplasty and stenting.
Area of Science:
- Neurology
- Vascular Medicine
Background:
- Multiple sclerosis (MS) is a chronic neurological disease.
- Zamboni et al. (2009) proposed a link between chronic cerebral venous congestion and MS development.
- Chronic cerebrospinal venous insufficiency (CCSVI) is a condition affecting venous drainage from the brain and spinal cord.
Purpose of the Study:
- To review the role of CCSVI in the pathogenesis of MS.
- To evaluate the efficacy of venous angioplasty and stenting for treating CCSVI in MS patients.
Main Methods:
- Literature review of studies investigating CCSVI and MS.
- Analysis of evidence for endovascular treatments for extracranial venous stenosis.
Main Results:
- Evidence suggests a correlation between CCSVI and MS.
- Venous angioplasty and stenting show potential as therapeutic options for MS patients with CCSVI.
Conclusions:
- CCSVI is a potential contributing factor in MS.
- Further research is needed to confirm the causal relationship and long-term outcomes of venous interventions in MS.
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