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Cutaneous hyperpigmentation induced by doxycycline: a case series.

S P Keijmel1, M E E van Kasteren, W A M Blokx

  • 1Radboud Expert Centre for Q fever, Departments of Internal Medicine, Division of Infectious Diseases, Dermatology, Pathology, Radboudumc, Nijmegen, the Netherlands, Department of Internal Medicine, St. Elisabeth Hospital, Tilburg, the Netherlands, *corresponding author: tel.: +31(0)24-3618819, fax: +31(0)24-3541734,

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Doxycycline can cause skin hyperpigmentation, even at standard doses. This side effect, seen in four patients, resolved after stopping the drug, highlighting the need for prompt recognition.

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Area of Science:

  • Dermatology
  • Pharmacology

Background:

  • Cutaneous hyperpigmentation is a known side effect of tetracycline antibiotics.
  • Previous reports of doxycycline-induced hyperpigmentation are rare, involving only one patient at therapeutic doses and one at suprapharmacological doses.

Observation:

  • Four patients developed new-onset cutaneous hyperpigmentation.
  • The hyperpigmentation occurred in previously unaffected skin areas.
  • The patients were receiving therapeutic doses of doxycycline.

Findings:

  • Doxycycline treatment was associated with the development of cutaneous hyperpigmentation in four individuals.
  • Hyperpigmentation resolved in all patients after discontinuation of doxycycline therapy.

Implications:

  • This study expands the understanding of doxycycline's potential side effects.
  • Clinicians should be aware of doxycycline-induced hyperpigmentation, even with standard therapeutic dosages.
  • Timely recognition and cessation of doxycycline are crucial for managing this adverse reaction.