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Basic and clinical pharmacology contribution to extend anthelmintic molecules lifespan
Carlos Lanusse1, Adrian Lifschitz1, Luis Alvarez1
1Laboratorio de Farmacología, Centro de Investigación Veterinaria de Tandil (CIVETAN), CONICET-Facultad de Ciencias Veterinarias, UNCPBA, Campus Universitario, 7000 Tandil, Argentina.
Veterinary Parasitology
|July 30, 2015
Summary
Integrated pharmaco-parasitological research is vital for livestock parasite control. Understanding drug interactions is key to managing anthelmintic resistance and preserving novel drug efficacy.
Area of Science:
- Veterinary Pharmacology
- Parasitology
- Drug Resistance Management
Background:
- Pharmacology-based information is crucial for effective livestock parasite control strategies.
- Integrated pharmaco-parasitological approaches optimize drug activity.
- Anthelmintic drug combinations are used to manage helminth resistance in ruminants.
Purpose of the Study:
- To review integrated pharmacokinetic/pharmacodynamic and clinical pharmacology information for parasite control.
- To highlight the need for research into drug interactions in combined anthelmintic preparations.
- To summarize novel pharmacological data on derquantel and monepantel.
Main Methods:
- Literature review of integrated pharmaco-parasitological research.
- Analysis of pharmacokinetic and pharmacodynamic interactions of anthelmintics.
- Summary of clinical pharmacology and novel drug data.
Main Results:
- Combined anthelmintics may reduce individual worm resistance compared to single compounds.
- Potential pharmacokinetic/pharmacodynamic interactions between drug components require further investigation.
- Novel anthelmintics like derquantel and monepantel offer new tools for parasite control.
Conclusions:
- Integrated research is essential to understand the benefits and drawbacks of combined drug use.
- Preserving traditional and modern anthelmintics requires comprehensive pharmaco-parasitological knowledge.
- Securing the lifespan of novel molecules necessitates understanding their pharmacology and interactions.
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