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Nucleoside Triphosphates - From Synthesis to Biochemical Characterization
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Nucleotide binding interactions modulate dNTP selectivity and facilitate 8-oxo-dGTP incorporation by DNA polymerase

Matthew J Burak, Kip E Guja, Miguel Garcia-Diaz

    Nucleic Acids Research
    |July 30, 2015
    PubMed
    Summary

    8-Oxo-7,8,-dihydro-2'-deoxyguanosine triphosphate (8-oxo-dGTP) causes DNA damage. DNA polymerase lambda (Pol λ) discriminates against this oxidized nucleotide, preventing mutations.

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