Cellular prion protein (PrP(C)) and its role in stress responses

Investigation of the physiological function of cellular prion protein (PrP(C)) has been developed by the generation of transgenic mice, however, the pathological mechanisms related to PrP(C) in prion diseases such as transmissible spongiform encephalopathies (TSEs) are still abstruse. Regardless of some differences, most studies describe the neuroprotective role of PrP(C) in environmental stresses. In this review, we will update the current knowledge on the responses of PrP(C) to various stresses, especially those correlated with cell signaling and neural degeneration, including ischemia, oxidative stress, inflammation and autophagy.