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Urinary expression of acute kidney injury biomarkers in patients after RIRS: it is a prospective, controlled study

Onur Dede1, Mansur Dağguli1, Mazhar Utanğaç1

  • 1Department of Urology, Dicle University School of Medicine Dıyarbakır, Turkey.

International Journal of Clinical and Experimental Medicine
|July 30, 2015
PubMed
Abstract

Insights

Retrograde intra-renal surgery (RIRS) appears safe for kidney tissue. While kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) levels temporarily increased post-procedure, they returned to baseline within 24 hours.

Area of Science:

  • Nephrology
  • Urology
  • Biochemistry

Background:

  • Retrograde intra-renal surgery (RIRS) is a common procedure for kidney stones.
  • Assessing potential kidney tissue damage from RIRS is crucial for patient safety.

Purpose of the Study:

  • To evaluate the impact of RIRS on kidney tissue by measuring specific biomarkers.
  • To determine the safety profile of RIRS concerning acute kidney injury (AKI).

Main Methods:

  • Thirty patients undergoing RIRS for renal calculi < 2 cm were enrolled.
  • Urine samples were analyzed for kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), N-acetyl-β-D-glucosaminidase (NAG), and liver-type fatty acid binding protein (LFABP) levels.
  • Measurements were taken pre-surgery, 2 hours post-surgery, and 24 hours post-surgery, normalized to creatinine (Cr).

Main Results:

  • KIM-1/Cr and NGAL/Cr levels significantly increased 2 hours after RIRS compared to pre-surgery levels (P:0.04, P:0.02).
  • These elevated biomarker levels returned to baseline within 24 hours post-surgery.
  • NAG/Cr and LFABP/Cr levels showed no significant changes after RIRS.

Conclusions:

  • Based on AKI markers, RIRS is suggested to be a safe surgical method.
  • The transient increase in KIM-1 and NGAL indicates a temporary response, not sustained kidney damage.
  • The findings support the safety of RIRS for treating renal calculi.
Keywords:
N-acetyl-β-D-glucosaminidaseRetrograde intra-renal surgeryacute kidney injurykidney injury molecule-1neutrophil gelatinase-associated lipocalin

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