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Renal 123I-MIBG Scintigraphy Before and After Kidney Autotransplantation
Linn C Dobrowolski1, Daan W Eeftinck Schattenkerk, Mirza M Idu
1From the Departments of *Internal Medicine-Nephrology and Kidney Transplant Unit; †Internal Medicine-Vascular Medicine, ‡Vascular and Transplant Surgery; and §Nuclear Medicine, Academic Medical Center at the University of Amsterdam, Amsterdam, the Netherlands.
Abstract:
A 25-year-old man underwent an autotransplantation of his right kidney because of fibromuscular dysplasia-induced renal artery stenosis and subsequent hypertension. Since transplantation results in complete kidney denervation, it enabled assessment of renal sympathetic nerve activity changes using renal I-MIBG scintigraphy. Before and 2 weeks after transplantation I-MIBG, scintigraphy was performed. Uptake of I-MIBG in the left (control) kidney increased after transplantation with 4% at 15 minutes and 5% at 4 hours postinjection images, whereas I-MIBG uptake in the right transplanted kidney decreased with 21% at 15 minutes and with 29% at 4 hours, demonstrating renal I-MIBG changes after denervation.
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