Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Stem Cell Niche

Stem Cell Niche

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Nano-nebula superstructure decorated wood-derived biochar for efficient and rapid antibiotic degradation.

Nanoscale·2026

Same author

An immunocompetent bone marrow-on-a-chip model for studying human hematological malignancies and preclinical therapeutic screening.

Nature protocols·2026

Same author

Editorial Overview: Immunopathogenesis in viral disease.

Current opinion in virology·2026

Same author

Pharmacological intervention of the HMGB1-pCTS-L axis to ameliorate inflammatory diseases.

Frontiers in immunology·2026

Same author

Burden and Correlates of Multiple Chronic Infections and Their Associations With Cancer Incidence in Chinese Adults: A Large Case-Cohort Study.

International journal of cancer·2026

Same author

A scoring model based on oral contrast-enhanced ultrasound for the diagnosis of gastric cancer: A preliminary study.

Ultrasound (Leeds, England)·2026

Same journal

Dual-Modal Phototherapeutic Nanoagents Eradicating Drug-Resistant Bacteria via Multi-Pathway of Membrane Disruption, Oxidative Damage, and Energy Metabolism Interference.

Advanced healthcare materials·2026

Same journal

Smartphone-Enabled Point-of-Care Biosensing Platform With Self-Calibration for Rapid Matrix-Resistant Detection of Multiple AMI Biomarkers in Whole Blood.

Advanced healthcare materials·2026

Same journal

Multimetal-Doped Nanoenzymes Reprogram Macrophages for Immunotherapy of Gouty Arthritis.

Advanced healthcare materials·2026

Same journal

Correction to "Fibrosis-on-Chip: A Guide to Recapitulate the Essential Features of Fibrotic Disease".

Advanced healthcare materials·2026

Same journal

A Collagen-based Scaffold Supports Tendon-to-bone Healing After Rotator Cuff Repair: An Integrated Translational Study.

Advanced healthcare materials·2026

Same journal

A Biomimetic Copper-Caffeic Acid Nanozyme Activates Cuproptosis and Pyroptosis by Mimicking the Neutrophil Enzymatic Cascade.

Advanced healthcare materials·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Apr 6, 2026

Preparation of Tunable Extracellular Matrix Microenvironments to Evaluate Schwann Cell Phenotype Specification

Preparation of Tunable Extracellular Matrix Microenvironments to Evaluate Schwann Cell Phenotype Specification

Published on: June 2, 2020

Engineering nanoscale stem cell niche: direct stem cell behavior at cell-matrix interface.

Yan Zhang¹, Andrew Gordon¹, Weiyi Qian¹

¹Department of Mechanical and Aerospace Engineering, New York University, Brooklyn, NY, 11201, USA.

Advanced Healthcare Materials

|July 30, 2015

Summary

This summary is machine-generated.

Nanotopography, mimicking the stem cell niche, offers a promising method for controlling stem cell proliferation and differentiation in vitro. This technology is crucial for advancing tissue engineering and regenerative medicine applications.

Keywords:

biomaterials mechanotransduction nanotopography regenerative medicine stem cell

More Related Videos

Stencil Micropatterning of Human Pluripotent Stem Cells for Probing Spatial Organization of Differentiation Fates

Stencil Micropatterning of Human Pluripotent Stem Cells for Probing Spatial Organization of Differentiation Fates

Published on: June 17, 2016

Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes

Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes

Published on: April 12, 2015

Related Experiment Videos

Last Updated: Apr 6, 2026

Preparation of Tunable Extracellular Matrix Microenvironments to Evaluate Schwann Cell Phenotype Specification

Preparation of Tunable Extracellular Matrix Microenvironments to Evaluate Schwann Cell Phenotype Specification

Published on: June 2, 2020

Stencil Micropatterning of Human Pluripotent Stem Cells for Probing Spatial Organization of Differentiation Fates

Stencil Micropatterning of Human Pluripotent Stem Cells for Probing Spatial Organization of Differentiation Fates

Published on: June 17, 2016

Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes

Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes

Published on: April 12, 2015

Area of Science:

Biomaterials Science
Stem Cell Biology
Tissue Engineering

Background:

Extracellular matrix (ECM) biophysical cues significantly regulate stem cell behavior.
Controlled stem cell differentiation is essential for tissue engineering and regenerative medicine.
Understanding cell-microenvironment interactions is key to harnessing stem cell potential.

Purpose of the Study:

To review the advancements in nanotopography for controlling stem cell behavior.
To explore fabrication methods and the impact of nanoscale patterns on stem cells.
To investigate potential intracellular mechanisms mediating nanotopography's effects.

Main Methods:

Review of historical and contemporary research on nanotopography.
Analysis of various nanotopographic fabrication techniques.
Examination of stem cell responses to different nanoscale patterns.

Main Results:

Nanotopography can effectively mimic the stem cell niche environment.
Specific nanoscale patterns influence stem cell proliferation and differentiation.
Fabrication methods are advancing for precise control over nanotopographic features.

Conclusions:

Nanotopography presents a viable strategy for in vitro stem cell manipulation.
Further research into intracellular mechanisms will optimize regenerative medicine applications.
This technology holds significant potential for large-scale stem cell control.