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Updated: Apr 6, 2026

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
06:54

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells

Published on: October 27, 2020

14.8K

[The TGF-β signaling pathway induced EMT in breast cancer]

Yan Ma, Hong Liu, Hao Zhang

    Yao Xue Xue Bao = Acta Pharmaceutica Sinica
    |July 31, 2015
    PubMed

    Insights

    Epithelial-mesenchymal transition (EMT) drives breast cancer metastasis and drug resistance. This review details how the transforming growth factor beta (TGF-β) signaling pathway regulates EMT in breast cancer progression.

    Area of Science:

    • Oncology
    • Cell Biology
    • Molecular Biology

    Background:

    • Epithelial-mesenchymal transition (EMT) is a cellular process crucial for embryonic development and wound healing.
    • EMT involves the loss of epithelial characteristics and acquisition of mesenchymal traits, enabling cell migration.
    • In breast cancer, EMT is linked to tumor progression, metastasis, and resistance to therapies.

    Purpose of the Study:

    • To review the role of the transforming growth factor beta (TGF-β) signaling pathway in inducing EMT.
    • To explore the mechanisms by which TGF-β signaling drives EMT in breast cancer.
    • To provide an overview of current understanding regarding TGF-β-induced EMT in breast cancer.

    Main Methods:

    • Literature review of scientific articles and research papers.
    • Analysis of studies focusing on TGF-β signaling pathways and EMT.
    • Synthesis of information on molecular players and regulatory networks involved.

    Main Results:

    • TGF-β signaling is a critical regulator of EMT in breast cancer.
    • Activation of TGF-β pathway leads to molecular changes characteristic of EMT.
    • EMT contributes significantly to the metastatic potential and therapeutic challenges in breast cancer.

    Conclusions:

    • The TGF-β signaling pathway is a key driver of EMT in breast cancer.
    • Understanding TGF-β-induced EMT is vital for developing targeted anti-metastatic therapies.
    • Further research into TGF-β signaling mechanisms can offer new therapeutic strategies for breast cancer.

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