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Related Experiment Video

Updated: Apr 6, 2026

Creation and Maintenance of a Living Biobank - How We Do It
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Setting Up a Haplobank: Issues and Solutions.

Jacqueline Barry1, Johan Hyllner2, Glyn Stacey3

  • 1Cell Therapy Catapult, 12th Floor Tower Wing, Guy's Hospital, Great Maze Pond, London, SE1 9RT UK.

Current Stem Cell Reports
|July 31, 2015
PubMed
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This summary is machine-generated.

Induced pluripotent stem cells (iPSCs) enable scalable regenerative medicine therapies. Establishing a global iPSC haplobank requires international collaboration on manufacturing standards to prevent fragmented development.

Area of Science:

  • Regenerative Medicine
  • Immunology
  • Biotechnology

Background:

  • Induced pluripotent stem cells (iPSCs) present a scalable manufacturing solution for regenerative medicine.
  • Donor selection based on human leukocyte antigen (HLA) systems can minimize immunological rejection and reduce the need for immune suppression.
  • Broad availability of iPSC lines necessitates international agreement on common standards.

Approach:

  • The development of a global Good Manufacturing Practice (GMP) iPSC haplobank is proposed.
  • International collaboration is essential for defining optimal HLA panels, donor selection, screening, consent, GMP, quality control, and regulatory frameworks.

Key Points:

  • Scalable cellular therapies for regenerative medicine.
  • Minimizing immune rejection through HLA matching.
Keywords:
Good manufacturing practiceHLA matchingInduced pluripotent stem cells

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  • Need for global standards in GMP iPSC manufacture.
  • Addressing challenges in establishing a global iPSC haplobank.

    • Conclusions:

    • International agreement on common standards for GMP iPSC manufacture is urgently needed.
    • Proactive collaboration can prevent fragmented development in the iPSC field.
    • A global iPSC haplobank can advance regenerative medicine therapies worldwide.